Nicomenthyl® 20 is a multifunctional sensorial active ingredient derived from vitamin B3 (i.e. niacin or nicotinic acid), manufactured in Italy by Multichem R&D with a patented synthesis process.
Nicomenthyl® 20 significantly enhances skin microcirculation, without causing hyperemia or irritation. Instead, it produces a pleasant localized tingling sensation.
Vitamin B3 is a precursor of the coenzyme NAD (Nicotinamide Adenine Dinucleotide), one of the most interesting and important molecules in cellular energetic metabolism. Defined by some researchers as “the molecule of life”, NAD is required for over 500 enzymatic reactions and plays a key role in the regulation of almost all major biological processes, including our immune responses and DNA repair against damage caused by aggressive chemicals or radiations.
Niacin deficiency in keratinocytes, and consequent lack of NAD, causes intracellular events which can lead to lipid peroxidation, oxidative stress of cell membranes, premature skin ageing, erythema and skin irritation, and eventually to more serious consequences, including irreversible DNA damage, loss of epidermal barrier integrity, mutagenesis, immune suppression, actinic keratosis, and skin cancers.
A recent study, published in prestigious journal Nature, has also shown that vitamin B3 is highly effective even in preventing lung tissue inflammation damage in COVID-19 patients.
